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New Concerns Regarding Use of Bisphosphonates (Fosamax, Actonel, etc)
Submitted by midian on 20 February, 2009 - 18:15
Story Digest: 
Bisphosphonates are a class of drug usually prescribed to treat Osteoporosis, but sometimes also prescribed to AVN/Osteonecrosis patients as a way to try and slow down bone degeneration and resorption in necrotic lesions. Orally administered Fosamax and Actonel are the most common Bisphosphonates used to treat AVN.

This story describes that the FDA has recently issued a warning that orally administered bisphosphonates significantly increase the risk of developing esophageal cancer. 

The FDA recently issued a warning of a possible increased association of esophageal cancer and oral bisphosphonates use. From October 1995 through May 2008, the FDA reviewed reports of 23 patients in the U.S. with a new diagnosis of esophageal cancer that was felt to be related to alendronate use. In Europe and Japan, 31 cases of esophageal cancer were identified as possibly related to bisphosphonate use. A few of these patients had a diagnosis of Barrett’s esophagitis, which is known to increase the risk of esophageal cancer.
Even considering the increased risks, there are still many very significant possible benefits to bisphosphonates. For example, medical studies have proven that bisphophonates can help slow some forms of life-threatening necrosis. On the other hand, some top AVN/Osteonecrosis orthopedic surgeons feel that bisphosphonates can interfere with natural healing and regeneration of vascular tissues. As with any medication, it is important to discuss and weigh possible risks and benefits with your doctor.

 

Original Story Link: 
http://www.emaxhealth.com/2/94/29149/new-concerns-regarding-use-bisphosp...
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